Introduction Esophageal squamous cell carcinoma (ESCC) is one of the most aggressive forms of esophageal cancer and often presents treatment challenges due to its resistance to chemoradiotherapy (CRT). A recent study titled "Decreased plasma gelsolin fosters a fibrotic tumor microenvironment and promotes chemoradiotherapy resistance in esophageal squamous cell carcinoma" sheds light on an intriguing factor…